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Xylazine is appearing in street drugs across the US, and it’s raising serious alarms. Nicknamed the “zombie drug,” it’s a veterinary tranquilizer that isn’t safe for humans. Even small amounts can slow your heart, drop your blood pressure, and slow breathing without warning.
Even more alarming is how fast it’s spreading. In just a few years, labs across the country have found more and more street drugs contaminated with xylazine. The biggest jumps were in the South, but it’s showing up everywhere. In one multi-city review, xylazine was almost nonexistent in overdose deaths back in 2015, under 1%. By 2020, it was involved in nearly 7% of cases.
Local testing shows even higher numbers. In Maryland, almost 8 out of 10 drug samples that contained opioids also had xylazine. And in Philadelphia, Pennsylvania recent reports found it in roughly a third of heroin or fentanyl overdose deaths.
Xylazine is an animal tranquilizer and sedative used in veterinary medicine. For animals, it works safely under supervision. For humans, even small amounts can have profound effects. It slows the central nervous system, reduces heart rate and blood pressure, and causes extreme drowsiness.
When mixed with synthetic opioids like fentanyl, the combination is hazardous. The opioid slows breathing, and xylazine adds extra respiratory system suppression. Together, they can cause slowed breathing, drug-induced coma, or even death.
The problem is that people using street drugs usually don’t know xylazine is present. It’s often added without warning. And unlike opioids, naloxone alone may not reverse the effects of xylazine. That’s why overdoses with xylazine are harder to treat and more deadly.
Xylazine is not your typical street drug. It’s a veterinary tranquilizer designed to sedate large animals. That’s the first red flag, it was never meant for human bodies. When people take it, whether intentionally or unknowingly, the effects can spiral out of control quickly. Here’s what can happen:
Xylazine slows the central nervous system, which means your breathing can become dangerously slow. Combine it with opioids like fentanyl, and the risk of life-threatening respiratory depression skyrockets. Breathing may get so slow that oxygen can’t reach your brain correctly, which can lead to a drug-induced coma or death.
Xylazine can cause tranq wounds, deep, slow-healing ulcers at injection sites. They can appear even if the drug touches the skin without injection. These wounds are prone to severe infection, and untreated infections can become life-threatening.
Users may become extremely drowsy or move and speak very slowly, which is why people call it the “zombie drug.” In this state, it’s hard to stay safe, communicate needs, or respond in an emergency.
Xylazine rarely appears alone. It’s often mixed with synthetic opioids, cocaine, or other addictive drugs. Using multiple substances at once (polysubstance abuse) makes overdoses harder to treat, which greatly increases the chance of drug poisoning.
Even if naloxone is administered for an opioid overdose, it won’t reverse xylazine. That means someone could still experience slowed breathing, heart problems, or a drug-induced coma. Medical attention is critical, calling 911 can save a life.
Here are some common signs that you need to watch out for:
Naloxone is a life-saving antidote for opioid overdoses. But xylazine is not an opioid, so naloxone won’t reverse its effects. A person may still experience severe sedation, slowed breathing, or heart rate collapse even after receiving naloxone.
Harm-reduction experts emphasize getting immediate medical attention. CPR, oxygen support, and rapid transport to the hospital may be required alongside naloxone.
The safest and healthiest choice is to avoid street drugs entirely. They are unpredictable, often mixed with substances like fentanyl or xylazine, and can cause serious harm or death. If someone is struggling with substance use, professional treatment is the best way forward.
Still, we know some people continue to use. In those cases, there are a few things that can help prevent tragedy and protect lives:
Street drugs are often contaminated with dangerous additives. Fentanyl and xylazine are two of the most common, and both can cause rapid overdose. Because there’s no way to be certain what’s in a street drug, every single use carries serious risks.
Overdoses are more deadly when no one is there to help. Having someone nearby who can call 911 or get medical attention can mean the difference between life and death.
Shallow breathing, slowed heart rate, or unresponsiveness are medical emergencies. Don’t wait! Call 911 immediately if these symptoms appear.
Naloxone (Narcan) can reverse many opioid overdoses, though it won’t work on xylazine. Even so, it can save lives if opioids are involved. CPR and calling emergency services right away are also critical steps.
Wounds, infections, or other complications from drug use should never be ignored. These can quickly become life-threatening without proper medical care.
Street drugs are unpredictable and often far more dangerous than they appear. Fentanyl, xylazine, and other synthetic additives can be mixed in without warning. That means every dose is potentially life-threatening, even if it looks familiar. Treating street drugs as “unknown and unsafe” is the only realistic way to approach them.
While awareness and emergency measures can reduce risks, they don’t eliminate them. The only true way to avoid overdose and long-term harm is to stop using. Professional treatment provides medical support, safety, and the tools needed to break free from addiction. Recovery is possible, and help is available.
If you’re struggling with xylazine or other street drugs, the safest and most effective way forward is professional treatment. Some people try to quit on their own, but with xylazine, the risks are high and the worst could happen even with small amounts.
Treatment gives you support, guidance, and safety. In a professional program, you don’t just detox. You get help for polysubstance abuse, medical care for tranq wounds, and learn strategies to avoid relapse. You also learn how to recognize and manage the dangers of addictive drugs in a way that’s impossible to do alone.
You have options: you can try to quit yourself, but professional help dramatically increases your chances of staying safe and truly recovering. Drug rehab programs like More Than Rehab specialize in xylazine addiction treatment, helping people safely detox, heal, and rebuild their lives.
If xylazine is part of your drug use, don’t wait another day. Getting treatment now could save your life. Contact More Than Rehab to start your journey toward recovery.
